Developmental Programming in Animal Models: Critical Evidence of Current Environmental Negative ChangesReview Published on 2023-02-012023-07-09 Journal: Reproductive Sciences [Category] COVID19(2023년), [키워드] animal models gestation lactation Maternal programming metabolism New epigenetic factors. [DOI] 10.1007/s43032-022-00999-8 PMC 바로가기 [Article Type] Review
Enzymes in the time of COVID-19: An overview about the effects in the human body, enzyme market, and perspectives for new drugsArticle Published on 2022-11-012022-11-15 Journal: Medicinal research reviews [Category] COVID19(2023년), SARS, 치료제, [키워드] addition alanine aminotransferase angiotensin-converting enzyme-2 Aspartate aminotransferase Biomarkers cathepsin caused cholesterol contributed coronavirus COVID-19 drug drugs Effect effective effort enzyme enzyme market Enzymes Infection JAK/STAT pathway lactate dehydrogenase M pro mechanism of action metabolism pandemic Papain-like protease pathway Perspective protease reported Research rising SARS-CoV-2 SARS-COV-2 infection Serine syndrome target enzymes. transmembrane Treatment virus [DOI] 10.1002/med.21919 PMC 바로가기
SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expressionArticle Published on 2022-11-012022-11-16 Journal: Life sciences [Category] SARS, 유전자 메커니즘, [키워드] A549 ACE2 ACE2 expression angiotensin ATP synthase autophagy BEAS-2B Brain Caco-2 can be used Cell cell line cell lines cellular cellular metabolism COVID-19 COX endothelial energy metabolism evaluated expression level HEK-293 human cell human cell line in vitro intestine intrinsically investigated kidney liver mechanism metabolism Mitochondria mitochondrial metabolism modified cell line molecular mechanism mRNA expression NDUFS2 overexpressed overexpressing overexpression Protein Replication replication kinetics respiratory tract RT-qPCR SARS-COV-2 infection SARS-CoV-2 replication SH-SY5Y susceptibility susceptible cell TMPRSS2 TMPRSS2 expression TMPRSS2. uninfected cell various tissue viral infection Viral load viral replication were assessed western blot [DOI] 10.1016/j.lfs.2022.120930 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기
Targeting T cell (oxidative) metabolism to improve immunity to viral infection in the context of obesityReview Published on 2022-10-062023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] Coronavirus disease 2019 (COVID-19) Influenza metabolism metformin obesity. T cells [DOI] 10.3389/fimmu.2022.1025495 PMC 바로가기 [Article Type] Review
Association of Midgut Bacteria and Their Metabolic Pathways with Zika Infection and Insecticide Resistance in Colombian Aedes aegypti PopulationsArticle Published on 2022-10-062022-11-16 Journal: Viruses [Category] 유전자 메커니즘, 치료기술, [키워드] ABC Aede Aedes aegypti affecting Analysis analysis analyzed Bacteria Bacterial Bacteroide changes in Chikungunya Combination condition COVID-19 pandemic Defense Degradation disease Dysbiosis effective evaluated female females function functions generate Honda Host identify Infection infection control infection rate infections infective insecticide insecticides Interaction intestinal intestine knowledge lack lambda-cyhalothrin limitation Local management mechanism metabolic metabolism microbiota microcephaly midgut midgut. modulated Mutation natural infection outbreak pathogenicity Population populations predict predicted prenatal Pseudomona resistance risk RT-PCR significantly sodium South America Surveillance susceptibility susceptible syndrome Transmission Treatment Vaccine vector control Viral transmission virus entry was related Zika Zika virus ZIKV [DOI] 10.3390/v14102197 PMC 바로가기
Calibration and Validation of a Mechanistic COVID-19 Model for Translational Quantitative Systems Pharmacology – A Proof-of-Concept Model Development for RemdesivirArticle Published on 2022-10-012022-11-15 Journal: Clinical Pharmacology and Therapeutics [Category] COVID19(2023년), SARS, 치료제, [키워드] accelerate Administered antibody approach calibrated calibration clinical Clinical data Clinical outcome clinical setting clinical study Clinical trial design coronavirus disease Course COVID-19 COVID-19 disease COVID-19 therapeutics Cytokines development disease drug candidate example global pandemic immune responses immunological in silico include intravenously lymphopenia metabolism metabolite Mild Model Patient pharmacological Pharmacology Placebo predict provide quantitative framework Remdesivir responses severe COVID-19 System the disease the primary endpoint Therapies therapy Time to recovery translate validation viral titer virus infection [DOI] 10.1002/cpt.2686 PMC 바로가기
Systematic virtual screening in search of SARS CoV-2 inhibitors against spike glycoprotein: pharmacophore screening, molecular docking, ADMET analysis and MD simulationsArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] absence acting acute respiratory syndrome Amino acid Analysis Anti-viral binding site catalytic coronavirus disease Coronavirus-2 COVID-19 distribution docking score effective Entry inhibitor glycoprotein host cell in silico inhibitor Interaction less Ligand MD simulation MD simulations medications metabolism molecular molecular docking nucleic acid offered performed Precision research finding residue SARS CoV-2 spike spike glycoprotein spike glycoprotein. stability starting point target Toxicity viral entry Virtual screening [DOI] 10.1007/s11030-022-10394-9 PMC 바로가기
Metabolomics-based investigation of SARS-CoV-2 vaccination (Sinovac) reveals an immune-dependent metabolite biomarkerArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] analyses Analysis antibodies and cytokines antibody association AUC Biomarker boost butanoate collected COVID-19 COVID-19 vaccine Cytokines determine effective fatality FDR Fold change GABA Glutamate greater help Host host immunity IgA IgG IgM immune Immunity IMPROVE individual indole Infection L-glutamic acid metabolism metabolite metabolome metabolomic metabolomic analysis metabolomics mutant strain mutated Pathways positive pre-vaccination provide respond reveal SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 virus infection sera serum serum antibody serum. Sinovac Spread Taurine vaccination Vaccine VIP Volunteer was performed [DOI] 10.3389/fimmu.2022.954801 PMC 바로가기
Clinical studies of detecting COVID-19 from exhaled breath with electronic noseArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 치료기술, [키워드] Accuracy affecting Analysis breath can be used clinical continuous monitoring coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic detect diagnostic methods exploratory gold standard help hospital limit Local metabolism Non-invasive Numerous pandemic Patient PCR point-of-care test polymerase chain problem reported Research Schools spread of COVID-19 Treatment viral infections virus infection VoC VOCs [DOI] 10.1038/s41598-022-20534-8 PMC 바로가기